BIOLOCHANICS
BIOLOCHANICS was a-five year project aimed at
achieving patient-specific predictions of aneurysm risk of rupture and of
aneurysm reactions to biochemical treatments.
Rupture of Aortic Aneurysms (AA) kills more than 30000
persons every year in Europe and the USA. It is a complex phenomenon that
occurs when the wall stress exceeds the local strength of the aorta due to
degraded properties of the tissue. The state of the art in AA biomechanics and
mechanobiology revealed in 2014 that major scientific challenges still had to
be addressed to permit patient-specific computational predictions of AA rupture
and enable localized repair of the structure with targeted pharmacologic
treatment. A first challenge related to ensuring an objective prediction of
localized mechanisms preceding rupture. A second challenge related to modelling
the patient-specific evolutions of material properties leading to the localized
mechanisms preceding rupture.
We worked at addressing these challenges in
BIOLOCHANICS.
We developed digital twin framework for helping
clinicians to establish prognosis for patients harbouring an AA. Thanks to
Magnetic Resonance Imaging and computer fluid dynamics simulations, we estimate
hemodynamics loads on the aortic wall. The impact of
the hemodynamics loads on the mechanical properties
aortic tissue and aortic smooth muscle cells has been extensively characterized
throughout the project. Eventually we simulate the induced evolutions through
finite element models to predict aneurysmal progression and potential risk of
rupture.
A first group of patients is currently evaluating this
digital twin framework which has been summarized with the following schema.
The Biolochanics project has led to the publication of 45 publications in
international journals, 1 patent. Numerous students and
postdocs have worked in this project and major international
collaborations have been initiated.
The following 5
journal papers give a nice overview of our scientific achievements:
1. Biaxial rupture properties of ascending thoracic aortic
aneurysms. Acta Biomaterialia, 2016,
2. Multimodality imaging-Based characterization of Regional
Material properties in a Murine Model of Aortic Dissection. Scientific
Reports, 2020.
3. Relationship between ascending thoracic aortic aneurysms hemodynamics and biomechanical properties, IEEE
Transactions on Biomedical Engineering, 2019
4. Regulation of SMC traction forces in human aortic
thoracic aneurysms. Biomechanics and Modeling in Mechanobiology, 2021.
5. Coupling
hemodynamics with mechanobiology in patient-specific
computational models of ascending thoracic aortic aneurysms. Computer
Methods and Programs in Biomedicine, 2021, 205, 106107.